UUIDs are generally generated randomly. This results in terrible insert performance into B+tree-based indexes, and terrible (= no) lookup locality with basically any database. In a large table, successive entries ends up in separate disk pages.
Even with time-based UUIDs, the time fields are ordered backward, which produces the same issue.
One way to fix this (beside the methods outlined in the article) is to create time-based UUIDs with fields sorted the other way around. Or reverse the time fields during indexing (slower, but still not as slow as an unnecessary disk read!).