Not just SSRIs. I had a very bad experience with Mucinex D (or DM?) about 12 years ago, the first time I tried it. I can only imagine it was what clinical depression is like. For two days (until I stopped taking because I was so scared) I lost all interest in my life. I wasn't interested in my young children, ow my wife, or watching anything on TV I usually like, or playing a game. I was questioning my work life choices as well because nothing at work held the slightest interest. I would go home, do what was required of me, then sit in bed and stare at the wall until I went to bed.
That is, to this day, one of the scariest experiences in my life. I've since heard of one or two other people that had similar experiences with it.