it's very likely that it's one of the cases that when reducing cache misses does really matter it's very different from using as little space as possible, and the degree to which it matter dwarfs the degree to which it's not a frequent concern (i.e. fat tail).

for example, if I have a struct that contains a bunch of atomic fields, I may actually want to control the layout to ensure they are far apart (even inserting padding) to prevent e.g. false sharing https://en.wikipedia.org/wiki/False_sharing.