Obviously mitigations won't help if you're blasted in the face by an airburst (nuclear or biological), but it seems like it could still help if you're on the fringe of exposure.
[edit]: maybe some of the more "extreme" (n95 masks, etc) have some decent level of protection, but I'm not sure anybody knows, at least with this variant. Even for previous variants all I've seen so far are models, which as we all know have a lot of assumptions.
It seems active / non-retired people will have a hard time avoiding it but after all the current wave will stop like the others so maybe I'm wrong.