Most of the unvaxxed are in places without access to vaccines and those populations will continue to be a source of new variants. Delta and Omicron both came from places/times that had very limited access to vaccines.
If someone in the US continues to reject vaccination, I don't know what to do about it at this point. But there's big populations that haven't been vaccinated because they haven't had a chance. It's crucial to give them that chance.