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Python has an interface called WSGI (web server gateway interface), with both Apache and Nginx you need either a none standard module for that interface or to reverse proxy to a second server that does.

So same number of moving parts either way.

How is libapache2-mod-wsgi-py3 "none standard"?

I meant it’s not built in as standard when you install apache, it’s an extra thing to install (even if it runs in process).

Apache has mod_wsgi, nginx not so much.

mod_wsgi is a much less flexible setup when it comes to mixing and matching different python versions

Gunicorn is not just a static content server (actually I don’t think it can serve static content out of the box?) but a wsgi-compliant application server. You can’t leave it out because then, how would your python web backend run?

For apache, there is libapache2-mod-wsgi-py3

Seems easier to just "apt install libapache2-mod-wsgi-py3" and put a "WSGIScriptAlias" directive into your apache config than to run another piece of software?