New info about cellular death process previously thought to be irreversible

I read TFA. It was a roundabout experience.

The cookie policy is explained as if there is some semblance of user choice, but actually there is none. You have to accept performance cookies, functional cookies, and Targeting cookies because they don't offer opt out at all, despite offering what looks like a UI tier. But they only offer this guidance:

> We have divided the Cookies we use into the following categories: Strictly Necessary, Performance, Functional, and Targeting. Under each category heading below you will find a general description of the Cookies in each category. You can change your browser settings to block, delete, or alert you to Cookies. The Help menu on the menu bar of most browsers will tell you how to do that. However, if you do, you may have to manually adjust preferences every time you visit a site and some features may not work as intended.

The article itself has a headline that seems to suggest cellular death processes have been found to be reversible, or at least, not irreversible. But the text reveals that the research finding is not anything to do with reversibility. Rather, it is about interruptibility.

When they install an optogenetic switch in the organism to trigger the process, it functions as an On/Off switch. But there is no reverse switch, in the same way that there is no On/Off switch for the tracking cookies.

TFA, on one level, is an exercise in creating expectations for switches that don't exist.

I still find it extremely interesting to study the venerable Ginkgo biloba and how the tree achieves near immortality https://www.science.org/content/article/how-ginkgo-biloba-ac...

I suspect the extremely slow ability to adapt to environmental changes led the tree to near extinction so in the end near immortality is not a good strategy when there is a need to adapt.

>Pyroptosis is a series of biochemical reactions that uses gasdermin, a protein, to open large pores in the cell membrane and destabilize the cell.

> They discovered that certain conditions, like specific concentrations of calcium ions, for example, triggered the pores to close within only tens of seconds.

They dont say what specific calcium concentrations are in comparison to normal concentrations, but ageing and a variety of diseases are linked to calcium & phosphorus (phosphate) build up in a variety of organs.

So the question is, is calcium a silent killer or delaying the inevitable?

Considering K1 is taken up by many cells extremely quickly into the Rough Endoplasmic Reticulum, I wonder how that alters this experiment?

Does this means that a cell can go from a senescent state (pre-apoptosis) to a healthy state? I was the first to postulate this possibility on reddit and this is a key question regarding the benefice/damage ratio of using senolytics.

It is very important to create awareness to all the billionaires out there that there is an alternative path to death or extension.