I don't really understand the goal.
Seems niche and fun to me. Not that I'll participate. I made a website once, never again.
I'm probably just too much of a control freak to deal with the uncertainty of browser-craft. (All respect to those who do web stuff) I'm from a painterly background and do cgi. If I want a pixel somewhere I'll put it there.
If you just use HTML, then the words that you choose to write will be the words that everyone will read.
Any "pixel placement" is optional and shouldn't be a detering factor.
I meant 'pixel' as a synecdoche, to stand in for all the elements of computer art and visual craft.