Input has been the main constraint, but using the Logitech K830, which was specifically integrated by Oculus as a proof of concept, with the latest passthrough hand positioning in Infinite Office mode -- there is no difference to typing at a normal keyboard anymore. Its amazing. The Oculus Web Browser is pushing what you can do with things like PWAs (Miro has one) and support for SaaS tooling like Office 360 for example - so you dont even need the PC.
The experience of working in VR is definitely rough arround the edges today but my expectation is this will improve to the point where XR (VR/AR) is just as normal as sitting at a desk today -- but with the additional benefits of a 3D space made open to imaginative enhancement.