"I think in English this never happens as unlike Hebrew, I can't think of a letter than can act as a meaningful prefix."

a on its own can be a few different prefixes: https://www.etymonline.com/word/a-?ref=etymonline_crossrefer... Many of the examples cited in that will strike a modern English speaker as simply being the word, such as "amethyst" which was news to me, but we have moral -> amoral, sexual -> asexual, and a few others.

I certainly agree I've never thought of this in the context of a word game, as opposed to the s suffix which is almost mandatory in Boggle, for instance.