In the NLP space there's been a lot of work recently around reducing model sizes, since they've started to reach the point where model weights sometimes don't fit in the memory of most GPUs.
There's also projects like MarianNMT which completely abandon Python and write heavily optimized models with fast languages that can run quickly and accurately even without GPUs. I think we'll see a lot more of this, though of course there's a pretty big barrier in the sheer rarity of being good at both deep learning research and writing optimized low-level code.