Yes it's possible ( https://www.ha-obsession.net/2017/05/u2f-sudo-fedora-25.html... and some other guides exists ) and I used it for about a year. I stopped using it. I was so annoyed to plugin the key every couple of hours that I simply kept the yubi key plugged in all the time - free to be picked by anyone and def. not increasing security.
We still use it for SSH and its great!