Can we have a space station at L2? That'd be awesome. I am sorry but if I make it big like Elon I will be moving to L2. Take WFH to a new level.
Certainly, any protocols based on handshakes would be a non-starter even at lunar distances (384,000 km, 1.28 light seconds), let alone interplanetary ones (20 minutes to Mars, up to 90 minutes to Jupiter).
At interstellar ranges, the problem becomes even more complex, with keys taking years to be received.
There are some preliminary discussions of space-based IP communications. I do suspect that UDP would be preferred over TCP, for obvious reasons.
Your body is built to expect gravity to pull blood down. The circulatory system thus pushes blood up. When in space this creates problems.