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Depends on your definition of primary and secondary effects. I count future efficacy as a primary effect, wouldn't you? Do we know what vaccine efficacy will be in 2 years? Answer: No, exhibit: Omicron. Most drugs don't have to fight a moving target.

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Huh? What about all other vaccine, antibiotics and antivirals? When would you say is the "experiment" concluded. I mean I could always say: yeah it fared well for 40 years but what about 50? Do you know? Ergo still an experiment according to you.

Are you claiming we don't know the primary impacts of those? Do we have good reason to believe they will change at year 50? My point is that we don't know primary impact even short distance out and we have reasonable evidence that the nature of our opponent is the problem, not the technology.

Antibiotics do, so do antivirals and antifungals.

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