This is a key point. The simulated universe is unfalsifiable, meaning that there is no experiment we can (currently, perhaps forever) perform that could prove it true or false. Even if we could conceive of such an experiment, simulation advocates could argue that the simulation was set up to produce the results we see.
Also, it's worth bearing in mind that simulation is really hard and computationally expensive: we cannot yet model a single human neuron at the atomic level, let alone at the quark level. You can try to get around this detail by saying that the simulation focusses computation / resolution on where we are looking, but this again seems to be moving the goalposts.
I would like a simulation proponent to propose a credible laws of physics for the host universe, as well as making some comments about how computation (i.e. simulation) works in that universe. For example, is the host computation subject to the same theoretical constraints that our computers are, e.g. the halting problem, and P versus NP.
[Edit] minor rewording for clarity.