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Comment by tepitoperrito | Hacker News Reader

I'd stay far away from any compound in the 25x-NBOMe series. The risk of life threatening episodes are real and understated in TFA with erratic responses to even low doses in experienced and first time users.

One summer when 25i first hit the scene SWIM was taking 1000 to 5000 microgram doses weekly until one week SWIM dosed 1000 micrograms (pre dipped blotter) and the short version of the story is SWIM woke up in the hospital and was being monitored to prevent kidney failure due to elevated proteins in SWIM's blood.

Similar events which were all preceded by psychotic breaks with reality happened to quite a few of SWIM's friend group if you want some anecdata to add there.

It's scary stuff whose unpredictability means I wouldn't recommend touching it with a 10 foot pole.

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The whole NBOMe/NBOH series are notorious for that. Some people have incredible visuals and a gentle time, others go psychotic or randomly die.

There are other dangerous phenethylamines, of course. Bromo-DragonFLY caused vasoconstriction which resulted in amputations or strokes in overdose, many others including the 2C-Ts are MAOIs. And even LSD has catastrophic effects when taken with lithium. But there's something about the NBOMes, maybe off-target effects, that makes them terrifying.

...which is a shame because having a new backbone to play with would be super fun. we have phenethylamines and tryptamines and ergolides, but there's only so much you can tweak them. hopefully - eventually - Shulgin's style of gonzo pharmacology will be allowed again, and someone will discover more magic keys.

Can't edit my post anymore, but researched and (some of?) the NBOMe toxicity appears to be from rhabdomyolysis (your muscles break down, releasing proteins that cause your kidneys to fail.)

Source: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5552826/

They reproduced it in zebrafish, apparently. They suggest using 25B as an actual research chemical to study serotonin-induced rhabdo in lab animals shudder.

FYI, SWIM means "somebody who isn't me", often used on drugs forums.

In that case, it sounds just like transparent obfuscation in the vein of "asking for a friend"

It's been a long time since I heard anyone say SWIM. I thought we all recognized that it wouldn't hold in a legal context and was thus unnecessary. I dont know if it was true but I distinctly remember that conversation happening at least a couple times in a couple places and the use of SWIM fading out after.

Well that's not good.

From what I could tell back then, 'I' was the most likely to cause problems. B and C seemed to be relatively well tolerated, though not trouble-free.

The universe works in funny ways when absolute euphoria or utter hell are just a different dice roll away.

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