> Of course the energy requirements are insane and would require some kind of physicists nightmare propulsion system like antimatter rockets. Lose reactor containment and you are instantly converted into plasma and gamma rays. If you hit something the size of a dust particle it will destroy your spacecraft.

And, this one spacecraft needs to be able to slow down, have the telescopes and equipment needed to identify exoplanets and decide they are suitable, have the means to travel all the way there, and have everything aboard to start a complete new viable colony on some unknown planet. It probably needs to bring all the energy for the first few millenna in batteries. That must mean a huge spacecraft, and there also needs to be some way to land it all on the planet, hopefully with all the pieces close to each other. Et cetera.

The engine that got all that close to light speed is just a tiny piece of the puzzle.