No amount of hard work would have allowed Stephen Hawking to succeed at sports.
Some pursuits are simply unavailable to those without the requisite immutable attributes. This is not politically comfortable, but it is true. I think the only legitimate question is whether mathematics is such a pursuit, and I'd like to be proved wrong on that point, but trying to convince me that anyone can do anything they put their mind to is wasted effort as it is so plainly contradicted by the available evidence.