Is this tweet wise and profound? Obviously not. Is there a kernel of useful information buried in there? Barely. As you said, is the purpose really just to elicit a reaction? Obviously, yes.
These kinds of remarks remind me of people who used to brag about getting good grades despite not doing the reading or homework, as if that's a virtue.
They're not harmless, because plenty of people will take away from this the idea that you don't need to do research on things, in general. Because Paul Graham is very rich and wise and he said so.
It's dumb fortune cookie wisdom, like so many of his wise and profound edgy, contrarian viewpoints.
Instead, the choice of a lean business plan (business model canvas) is also offered or at least talked through. Someone has an idea but isn't sure what to do next. Well a business plan can just be the very essentials (who do you plan to serve and how... what are you planning on actually doing and can you afford to do that)