The second ten years of my career, I worked with (and continue to work on) much more simpler systems, but the stack looks like this: React/Angular/Vue.js, Node.js/SpringBoot, MongoDB/MySQL/PostGreSQL, ElasticSearch, Redis, AWS (about a dozen services right here), Docker, Kubenetes. _This_ is exhausting.
When you spend so much time wrangling a zoo of commercial products, each with its own API and often own vocabulary for what should be industry standards (think TCP/IP, ANSI, ECMA, SQL), and being constantly obsoleted by competing "latest" products, that you don't have enough time to focus on code, then yes, it can be exhausting.