When this structure is fed to a EDR/HDR/FDR Infiniband network, the result is a blazing fast storage system where you can make a massive number of random accesses by very large number of servers simultaneously. The whole structure won't shiver even.
There are also other tricks Lustre can pull for smaller files to accelerate the access and reduce the overhead even further, too.
In this model, the storage boxes are somewhat sandboxed, but the whole model as a general is mounted via its own client, so the OS is very close to the model Lustre provides.
On the GPU servers, if you're going to provide big NVMe scratch spaces (a-la nVidia DGX systems), you soft-RAID the internal NVMe disks with mdadm.
In both models, saturation happens on hardware level (disks, network, etc.) processors and other soft components doesn't impose a meaningful bottleneck even under high load.