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I'm a little confused here. Wouldn't client DNS resolution performance really depend on your local DNS cache (e.g. the DNS server at your ISP)? Nobody going to your site will hit Route 53 or MediaTemple's DNS servers directly. These only serve as the source of truth for the thousands of DNS caches out there that clients actually hit.

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Typically this is true as the only performance hit will be due to the initial lookup, and then your resolver will cache the record. However, if your DNS record uses a low TTL (required for things like DNS-based monitoring/failover) like 30 secs or 1 minute, DNS lookups will have a larger impact on site performance because user resolvers will have to frequently re-query the authoritative DNS.

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