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Synergy (off which this was forked) experience: On a hardwired pair of computers, no perceptible latency at all. On wifi connected computers, I'd see the occasional latency spikes where things stop moving, but effectively imperceptible the rest of the time.

You don't strictly need a local network, you could probably get it to work across a VPN. As long as you can get a TLS connection directly between the two devices.

In my experience the protocol is quite light on the network, because this directly influences where the cursor is on your screen you probably want to keep latency down as much as possible.

I've been using synergy, literally, since the year 2000. I used to play a lot of first person shooters and over that time I never had a latency issue with using a mouse/keyboard on my old computer to play games on my new computers (over ethernet). No perceptible difference.

I've had issues running it over wireless so instead I connect the computers with an ethernet cable directly and configure static IP's. Haven't had any issues. Luckily my PC has two NICs and the laptop uses wifi anyway so the ethernet port is unused.