Depends on the device, I've had low-quality USB-C devices whose transfer speed inexplicably decreased when connected "the wrong way". Not knowing which orientation is the right one until you initiate the transfer is frustrating, and worse IMHO than physically preventing the wrong orientation.
Of course, this issue affects only a subset of mediocre hardware... But the fact that [1] this is possible is quite a downside to USB-C.
[1] https://hackaday.com/2021/03/22/cursed-usb-c-when-plug-orien...