Yes but his point is that if a 10% performance improvement is significant then you shouldn't be using Python!
Not to mention Python has Cython and numba's JIT which can provide great performance when needed.
l = [None] * 10_000
instead of rewriting parts of your application in C (possibly hiring new staff to do so).However, micro-optimizations and effective refactoring quickly add up and for us, improving the service response by 100ms via micro-optimization is better than improving it by 200ms via rewriting the entire service.