There is obviously a risk of pathogen leak..

https://armscontrolcenter.org/wp-content/uploads/2016/02/Esc...

And there are highly qualified experts in the field who view GoF research as the most likely source of COVID-19, so on what basis are you so confident that it doesn't pose a major risk?

Lab leaks (even without GoF involved) are remarkably common events.

So shouldn’t be base our regulation on that reality?

There have been many documented instances of lab leaks. It's even happened with Covid-19 research[1] at least once that was reported, and with the virus being pandemic around most of the world I'd assume there were many other leaks that weren't reported because nobody could prove it came from a lab. And even if the evidence that the original Covid-19 resulted from a lab leak is weak the evidence that the Omicron variant came from a lab is much stronger.

Scientists are only human and bio research labs don't have the same culture of continuous improvement and lack of blame that have let the airline industry, say, get to its current level of safety.

EDIT: Oops, forgot to add the citation

[1] https://fortune.com/2021/12/10/taiwan-investigates-covid-lab...