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You talked about changing your mind and transforming as a person, not doing great science.

> But I’ve not heard of anyone doing great science (or great anything really) because they went on a trip.

Kary Mullis claims to have come up with the idea for PCR while on an LSD trip, though he also said a lot of nonsense so I'm not sure you should be too much weight on that.

But he also mentioned in one of his popular books about his own experiments in this regard that he stopped playing with these things because he considered the health of his brain too valuable for that.