I said it upthread but maybe it's better to use the conceptual model of "chiplets but you don't cut the chiplets apart". You have some network of "chiplets" connected with some kind of interconnect (a mesh is the model everyone's used so far).
So a "chiplet" (a module) could still have some of its cores turned off, or be disabled entirely, and then you just route around them. The yields are thus the exact same you would expect from taking a wafer, printing a bunch of chiplets, and then not cutting it apart. Most of them (Zen3 is >90% with 8 functional cores now iirc) will be fine. A few will fail clock bins. A few will be dead. Etc.
https://cerebras.net/blog/wafer-scale-processors-the-time-ha...
A lot of the points you raise are fair, some of them can be engineered around and others not really.
* There is no reason that different "chiplets" can't have different clocks. big.LITTLE already deals with different clock domains and rates, your interconnect should be asynchronous and then it's just an aspect of the design. Maybe it's not desirable from a programming perspective but it's not a problem in hardware, and if you don't like an uneven canvas, then just disable those modules.
* However you can't do different voltages as easily. Having a FIVR (Fully-Integrated Voltage Regulator) in each "chiplet" is an option, just feed some high voltage like 2v or 3v and have the chip step it down. This is highly desirable for efficiency anyway. Or just feed a reasonably high voltage and if some of the chips don't clock well, then oh well, you use a little more voltage than necessary (Intel does this for Alder Lake - the chip uses the greater of "V_big" and "V_little" for whatever values are needed for frequencies at the moment - if the little cores get more voltage than they need, oh well). I don't think clock variations/chip quality generally varies as much as people imagine it does, especially once a process gets relatively mature, you can come up with some relatively good bars that almost all cores will pass.
* Wafer-scale chips have to be fabbed with everything on one process, that's true. With "tiles" and EMIB, or MCM, or regular stacking, you can mix and match them, including between vendors.
A lot of these "mix and match" bits don't really make sense/don't really fit the release model/don't really fit the physical engineering:
* A core block is already a self-contained (relatively) module that can be designed/tested/updated in isolation. Once you've got the bugs hammered out, scaling it arbitrarily large isn't a problem, and again, you probably are organizing it into "modules" of 8 cores or so anyway for organization's sake, even with wafer-scale.
* "version friction" is already a thing even in other chips. If RDNA2 isn't ready to go when AMD designs their Zen3 APUs... oh well, it doesn't go until the next generation. You could certainly iterate versions more quickly, but you can't change these behind your customer's back - if RDNA2 becomes available at some later date, you can't just swap it in, that's a new product and has to be validated and designed for separately.
* "steppings" already handle this in traditional chips. If there is some minor improvement in the memory controller, it becomes a new stepping of the chip. If it's a big change... it's a new release.
The big advantage of wafer-scale over current MCM/interposer tech at an engineering level is the much lower cost of data movement. MCM/interposer is expensive to push a signal all the way through a big interposer somewhere else, and it takes quite a lot of cache to even attempt to hide this. "Active interposer", EMIB, and advanced bonding technologies can help reduce this a lot, but it's "cheaper" to just push it to the module next to you and then have it pass the message along in turn.
MCM also really doesn't go to the scale wafer-scale does. What if I want a package with 64 CCDs on it? That's really what wafer-scale is about. But you can't do that with MCM since that's bigger than the reticle limit used to print an interposer. What you'd have to do is print "bridges" that go under the edges of the chiplets and carry the signal, and then mount the whole thing on an inert substrate (not printed like an interposer). And... that's exactly what EMIB does. But you'd have to do a ton of packaging work to get the size of chip that wafer-scale can gives you, each of those packaging stages (attaching each bridge, etc) has failure rates too. And from the sounds of it, it's actually quite high (AMD is supposedly taking a big hit on Milan-X yields due to the cache packaging step).