Some decisions might also seem more consequential to you than they are. Whatever job you pick, it will still be a job. Wherever you go, people will have the same basic interests and needs.
Many seemingly big decisions are also kind of reversible. If you quit your current job, you can always get another equally okay-ish job at a megacorp. If you move somewhere else, you can also move back. Only if you plan to start a family you might want to be close to your relatives, but YMMV.