In reality, the comment reflects four important things about Newton: 1 - marriage: he never married and once complained about someone trying to set him up with a woman; 2 - heresy: he was a reformation era figure, quite religious in his Protestant (heretical to some) beliefs; 3 - crime: as master of the mint he bestowed justice high (mostly) and low on forgers and other criminals within his authority (and not in Cambridge) which leads to 4 - sin: a nice intensifying noun that encompasses not only his intense religious nature but the zeal with which he pursued and punished criminals and many with whom he disagreed, including friends.