May I suggest looking at corporate sales enablement/internal education? Usually super nice people, well paid, not especially stress-y (at least in any healthy organization).
She's been focusing on those types of roles, but I worry she's not getting through due to not having experience with specific tools they use (e.g. Adobe Captivate). It feels to me like if she can just get someone on the phone she'd be a very strong candidate, but that first step is hard without knowing people.
Small, minor suggestion: maybe there are free, open source tools that are equivalent to what your wife might be expected to know...you being a techi can spin up some of these free tools, and she can gain some - though minimal - experience...and in her resume, or maybe cover letter tie her experience to these free tools as "similar to the industry standard set of tools...", etc. This helps because it inserts the keywords of industry standard tools, enabling the automated scripts to help get her on HR-system search results...but its not lying since the resume/CV states her experience is adjacent or something...and by then maybe a sympathetic hiring person might give her a shot? Obviously, this is a tiny tactic part of a greater set of strategies that she couild employ. ;-)
That's a good idea, thanks. We'll poke around and see what we can find.
I was actually thinking more about designing/teaching enablement classes - often live in many places - rather than using various goofy design apps for canned lessons. :)
Also HR positions. I know of several teachers who have gone into HR.