However, much of the problem is resolved if street parking is reduced or eliminated.
which direction is that, exactly? any cyclists or pedestrians coming the wrong way down the street will be in front of the vehicle. are you saying that drivers will exclusively look behind their vehicle while driving down a one-way street, and only very occasionally look in front?
No bends, turns, hills/humps, or other obstructions?
And what happens when a car and cyclist both go at a 20 mph pace? How much time does the driver have to react, if the cyclist doesn’t?
Setting that aside, this is the exact purpose of speed limits, not one-way streets. One-way streets do not prevent pedestrians from popping out behind "bends, turns, hills/humps, or other obstructions", or children, or debris, or potholes, or stopped or malfunctioning cars, or construction, or sudden road ends...
Edit: If you can't stop in time for a bicycle, you can't stop in time for anything, and you need to drive slower. Unfortunately, many American drivers seem to believe that they own the road, and if dumb children run out onto the road and get flattened, that's their own fault for breaking the law.
Are you suggesting cars go even slower?
When two vehicles move towards each other at 25 mph, that’s 50 mph.
It’s not 50 mph of automobile kinetic energy, but the human reaction time suffers the same.
Reacting to a 10 to 20 feet distance at 50 mph isn’t easy nor realistic, in roads designed for 25 mph travel.