HN (and myself honestly) might be a bit biased in favour of Lisps, but if one wanted an unambiguous notation for mathematics, Polish notation / s-expr style writing would be the way to go.

As for screen-readers -> parsing s-expressions and converting them into a more meaningful reading of the equation is within our power as well.

That's not to say that everything should be a lisp, but in terms of unambiguously applying mathematical formulae, I think (* f (+ x 1)) is very distinct from (f (+ x 1)).

¯\_(ツ)_/¯ mileage may vary I suppose. As someone who uses LaTeX a lot myself, I'm not sure I'd be fully happy writing Scheme / Lisp instead either. But I'm not sure the article really gives us less ambiguity purely thanks to an extra whitespace.