Colonizing another solar system, that's massively expensive. Sending a single interstellar missile at the planet though... that could wipe us out... and definitely seems possible without a huge expenditure of resources (for a civilization with mega-structures).
Missiles being much simpler because they don't have to support life, they don't have to slow down - and therefore don't need on board propulsion past what is needed for manoeuvring (assuming some sort of "push it with lasers" style of propulsion), and apart from systems needed for manoeuvring they can really just be a hunk of metal that you accelerate really fast.