psilocybin's come up is frightening/anxiety/panic inducing as it is....I don't think I can ever jump over ayahuasca, that seems like a whole different animal.
For me I feel like psilocybin "reset" my brain and there's some long lasting protection mechanism against depressive thinking. Even if I do feel down, something pulls me out of it. Whereas depression once it pulls you in, it likes to keep you there.
Do not take psychedelics lightly, especially ayahuasca and heroic doses. Even for the come up on psilocybin, it required considerable self calming and focused willpower to overcome the fear of losing ego. But my god, what comes after, the clarity, the peace, love and lingering positivity....zero chance the pharmaceutical community will be able to replicate it.