It’s definitely a tradeoff. I personally have gone through alternate phases where I wanted to be responsible for a huge piece of a small pie (startup) versus a tiny tiny piece of a huge pie (big company). There are pros and cons to both. The big slice of small pie feels cooler and more satisfying to my ego, but in the absolute sense the tiny piece of the big pie probably is actually making a bigger difference. 1% improvement at some of these companies means north of billions of dollars and improving hundreds of millions of peoples lives.