I run 4 monitors on 2560 resolution on two separate amd cards and everything runs flawlessly. I have all the software for free and most OSS is just as good if not better for my work (except games and Photoshop but photopea is a good alternative for that, and it can be easily my second nomination for this thread).
I know linux has evolved a lot and it's the effort of millions of volunteers which has made Linux what it is today, but for me personally Linux Mint really combines all the great things about linux into an amazingly elegant software.