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In practice? A major reason for the explosion in use of the herbicide glyphosate (RoundUp) is the use of genetically modified crops that are glyphosate resistant. Because of this users of these crops can dump huge volumes of glyphosate on their farms. This is a well known example of GMO’s leading to an increase in use of biocides.

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That's not really true. Intensive herbicide use in agriculture has been around for a long time. Sugar cane plantations used so much sodium arsenite in the 1800s that it regularly killed working animals and farm employees. Glyphosate was developed to be less toxic to humans and to require far less to be appied 100 pounds per acre vs 1 ton per acre of older herbicides. Yes, 1 ton per acre was the dosage rate for carbon bisulfide, borax, and arsenic trioxide prior to glyophosphate's development in 1974. Even when glyphosate is used as a desiccant it's still used at lower rates than the chemicals it replaced, and is far less dangerous for farmers.

Worth noting, the increase in desiccation practices, to prepare crops for a more scheduled harvest is also leading to a huge increase in glyphosate usage. It’s used high concentrations on crops at the last stage of crop growth just prior to harvest, in expectation of dry conditions which are ideal for harvesting, among other benefits.

https://ensia.com/features/glyphosate-drying/

You should find a reference that has statistics for how much this is done, because I’m not sure if it’s more than rare.

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