On the one hand, if they've bought into the notion that "we are all a family here" and that loyalty to their employer is like a familial obligation, and quitting their job is like abandoning an elderly relative on the street corner, then they may indeed be consumed by feelings of guilt and anxiety. Most observers would note that this is a false equivalency: the relationship between employer and employee is certainly not like that between parent and child.
One could likewise argue that quitting a job one hates is actually altruistic, as there are people who might like that job and if one's workplace is full of people who like what they're doing, it makes it a much more pleasant environment. Additionally, people who hate their jobs are known to take out their frustrations on family members, which is an unpleasant situation, so quitting a job one hates, even if it results in a somewhat lower standard of living, is not at all selfish - assuming one can find another job, and the end result is not poverty/homelessness.
Meditation would seem to be beneficial in any case. Some people don't even recognize that they hate their job as much as they do, and perhaps some internal reflection can suggest some changes that can be made to make the situation at least tolerable.
Incidentally, attempting to use things like guilt to motivate people to be obedient is a very unhealthy and Machiavellian tactic, and if 'mindfulness' helps people to break out of such situations, then the more the better.