One of the substantial sticking point issues, likely to be discovered by a developer who just made a dive into the Workers ecosystem, is the lack of full NodeJS compatibility. Taken for granted by people who didn't realise at first that Workers are not running on V8.

Hopefully open sourcing will stimulate the community, and maybe Cloudflare, to address the incompatibility issue. For example, to develop a shim emulating some filesystem APIs with underlying storage being as scalable as people expect from a filesystem and backed by either KV or upcoming R2.