Mythbusters did something like this, but it was just using one of those big commercial training simulators instead of a real plane if I recall correctly, and showed that it was possible.
In a situation where a non-pilot is pressed into flying an airliner because of pilot incapacitation, tiny municipal airstrips without ILS aren't really an option, anyway.
One would probably be able to coach a passenger through the steps necessary to get set up this kind of approach.