The NVMe off that second slot in particular is what's going to be painful for that market segment. If it weren't the topology that was only used specifically for the high performance market segment I'd say it doesn't matter but I'd be willing to bet most in that segment would actually want that 2nd x4 lane direct to the 1st chipset like last gen, not to the a second chipset just so they can have even more built in USB and SATA ports.
But who knows, maybe "I have a great gaming PC, it's got 25 USB ports!" (yes, that's the actual number) is more marketable than actually tuning for performance.