As O'Reilly said - you need to make it to the next gas station. If Elon Musk wants to launch rockets and make new car companies he's going to need to be profitable in that enterprise, or it's going to hurt a lot of people in a pretty short amount of time.
My point is this - he has to have profit as his main motive or he would fail. If you're going to change the world, you have to last long enough to do so. In order to do that, everyone involved has to be getting out more value than they are putting in. And that is profit.
Obviously it has to not go under but I bet he'd be happy driving on Mars in his solar-powered electric car if his companies made just enough to get by.
If by "main motive" you mean a minimum requirement then we agree. But for some that's just to get leeway to do the things they really want to do.
Define 'just enough to get by'.
Even if investors and employees are in it for a higher altruistic goal, they'll still want a good return on their time and money. Very few people are wont to just burn money so that someone else gets to enjoy playing CEO of a cool company. And even if they do enjoy it for a couple of years, the fun will soon stop.
Profit has to be the main motive for any long-term, successful enterprise. And the really big goals require really long periods of profitability to keep everyone interested and invested, whether with their money or their time.
I've noticed by your responses you think everyone who thinks any entrepreneur wants anything besides profit is "muddle-headed." The world is "muddled." Not everyone is playing the same game in life, for some people, money is the game, for some people, money is just something you need to play it. I've noticed some of the former types really want everyone to be playing the same game so they can measure up.
I don't think it's at all deceptive or muddle-headed to say that I'm really just hungry for a sandwich.
On the other side of the spectrum, there are non-profit companies. Some live without profit, based on donations, Others live as a "social corp" where all profits go to scale up growth, while keeping their main motive a non profit goal. Some of those non-profits can create huge changes.
In the middle you can also find lifestyle entrepreneurs. For many of those profit is not the main motivation.
So yes, there are successful entrepreneurs who are not motivated mostly by profit.