What I've imagined for the past decade or so, are spotter drones that are about the same size as the drones they are design to shoot down. These spotter drones could be built much like WW1/WW2 aircraft, just much smaller, with top speeds between 50-200knots for the smaller versions.
As a weapon, they could carry weapons similar to submachineguns, shotguns or light marchine guns, depending on the size of the target. Add an AI of about the same level of sophistication as the "autopilots" in cars, and they should be able to identify and shoot down hostile drones relatively cost efficiently. Produced at scale, the smallest versions (designed to shoot down comercially available drones, for instance), would not have to cost all that much more than the drones they are designed to shoot down, if produced at scale.
I'm imagining at least 3-4 size categories, lets say.
1) Tiny, able to shoot down most quad copters. Top speed of 50-100knots. Price needs to be low enough to allow tens of thousands to be produced. Could potentially also double as anti-infantry weapons by strafing.
2) Small. Able to shoot down switchblade-sized drones. Top speed of maybe 200 knots. Can be produced in numbers of thousands.
3) Medium. Sutable to hunt small UAV's, such as Buyraktar. Top speed of several hundered knots, maybe just below Mach 1. Somewhat more expensive than the Buyraktar, but can also carry some of the same ordanance, like a tiny fighter-bomber.
4) Full-sized, possibly supersonic. Basically the same as the Loyal Wingman concept. Designed to counter other full-sized drones as well as manned aircraft.
Basically, the removal of a pilot, allows aircraft to span a wide range of sizes, and I would expect all sizes to be produced, as it is uneconomical to hunt quadcopters with full sized aircraft, while it is impossible to hunt supersonic aircraft with switchblade type aircraft.
In a way, this would be analogous to naval vessels, with different sizes serving different roles, from corvettes, MTB's and attacks subs, through frigates and cruisers, to WW2 style batlleships or carriers.
Now, for the AI researchers out there, imagine the careers that can be built around providing AI's for these vehicles. To see your own AI locked in a WW2 style dogfight with a similar drone from another country, in a real-time feed.....