AV Linux probably has the best out-of-box audio production experience: http://www.bandshed.net/avlinux/

The maintainer, Glen MacArthur, is very active on the Linux Musicians forum and always willing to answer questions: https://linuxmusicians.com

Side note / self promotion, I'm the primary maintainer of Dragonfly Reverb, which is popular among folks that make music on Linux: https://michaelwillis.github.io/dragonfly-reverb/