Lab mice are probably evolving via artificial selection to be more prone to respond to drugs in a way that maximizes paper citations.
For me it looks too easy to have a successful experiment (and article) if you can choose how you poison the animal.
I have always wondered why they did not use a commercial model, and better tested their hypothesis on several, unrelated animal models.
Grow black mice that are hyperresponsive and white mice that are hyporesponsive (?) while optimizing for minimum genetic distance.
Sell them in equally weighted batches as yin/yang mice ("purely for esthetic reasons, also suitable for lab tests")