these advantages/disadvantages are widely known in the speed running community. They occasionally will have a calculation to normalize between regions where an in game clock is used due to PAL vs NTSC, but having more time while still having the same in game clock time is a competitive advantage and you will see all top records using a particular region platform.

A different trick in games that don't have an internal clock, but are instead timed by wall clock is to use a region platform where the text loads faster. For example for Zelda Ocarina of time, the Japanese Wii Virtual Console version is used almost exclusively because of faster text and loading times: https://www.speedrun.com/oot#100

As a developer I find Speed running extremely interesting. The creativity used to eek out performance gains is incredible.