This. Being a European, after seeing NYC, SF and Las Vegas, I passed on an opportunity to go for a week-long business trip to Seattle. Even though I had the time, I imagine Seattle being just mostly more of the same (an uniform, boring city consisting of XX century architecture built on a grid) and absolutely not worth the trip.
Americans speaking about large cultural differences between regions always surprise me - I often suspect they don't understand what "cultural differences" mean and instead talk about political differences.