"Asana is beautifully designed. Seems too generic for bug, applicant or project tracking but it's going to be my new To-Do list manager."
But to expand a bit -- I have a hard time seeing this replace specific purpose-driven tools (JIRA, Cerberus, etc.) even though it's gorgeous, functional, and has a cool off-line mode. It's just too generic for me. But for people who aren't coming from one of those products and have nothing today, it's a great way to introduce productivity. I'm surprised they didn't build in an SSO / LDAP kind of integration...
Finally - Salesforce focused on CRM as a use-case before branching out and getting less specific (support, chatter, etc.). Starting out generic requires your users to figure out how to apply it to their life, which I think is the wrong strategy.