A related thing I discovered recently is the potential non-atomicity of writes using O_APPEND on Linux[1], although I couldn't get the attached test program to fail on my machine. I would love to find some kind of confirmation that this behaviour has been changed and that appends can be relied upon to be atomic.
In the application I'm working on at the moment I've managed to get add more certainty around this stuff since I'm only ever appending to the file in 4096 byte chunks, so can perform a simple file size check to see if data was written completely or if the file needs to truncated to the nearest multiple of 4096. I'm fortunate that it prevents having to do something like open it read only to verify contents as you mentioned.